T-614 attenuates knee osteoarthritis via regulating Wnt/β-catenin signaling pathway

Abstract Background The aim of this study was to investigate the effect of Iguratimod (T-614) on rat knee osteoarthritis (KOA) and further to explore its underlying mechanism. Methods In this study, papain-induced KOA model was constructed. Hematoxylin and eosin (H&E) staining was conducted to obser...

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Κύριοι συγγραφείς:	Shan Cong, Yan Meng, Lingrui Wang, Jiao Sun, Ta bu shi·Nu er xia ti, Li Luo
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	BMC 2021-06-01
Σειρά:	Journal of Orthopaedic Surgery and Research
Θέματα:	Knee osteoarthritis Articular cartilage Iguratimod Inflammation Wnt/β-catenin signaling pathway
Διαθέσιμο Online:	https://doi.org/10.1186/s13018-021-02530-2
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