A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2–Beclin1 axis

Abstract Background Osteoarthritis is a common and progressive degenerative joint disorder marked by cartilage degradation, subchondral bone remodeling, and chondrocyte apoptosis. Autophagy, a tightly regulated intracellular degradation process, is essential for maintaining chondrocyte homeostasis....

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Prif Awduron:	Gongyin Zhao, Farbod Yousefi, Ichiro Tsukamoto, Steven Moran, Atta Behfar, Christopher Evans, Chunfeng Zhao
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	BMC 2025-12-01
Cyfres:	Journal of Nanobiotechnology
Pynciau:	Exosomes Autophagy Apoptosis BCL2 Beclin-1 Cartilage regeneration
Mynediad Ar-lein:	https://doi.org/10.1186/s12951-025-03807-y
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