A therapeutic-grade purified exosome system alleviates osteoarthritis by regulating autophagy through the BCL2–Beclin1 axis

Abstract Background Osteoarthritis is a common and progressive degenerative joint disorder marked by cartilage degradation, subchondral bone remodeling, and chondrocyte apoptosis. Autophagy, a tightly regulated intracellular degradation process, is essential for maintaining chondrocyte homeostasis....

ver descrição completa

Detalhes bibliográficos

Principais autores:	Gongyin Zhao, Farbod Yousefi, Ichiro Tsukamoto, Steven Moran, Atta Behfar, Christopher Evans, Chunfeng Zhao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-12-01
coleção:	Journal of Nanobiotechnology
Assuntos:	Exosomes Autophagy Apoptosis BCL2 Beclin-1 Cartilage regeneration
Acesso em linha:	https://doi.org/10.1186/s12951-025-03807-y
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!