Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro. Here we culture primary human fibroblasts a...

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Autori principali:	Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano, Martin Picard
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Taylor & Francis Group 2019-10-01
Serie:	Epigenetics
Soggetti:	aging dna methylation epigenetic age primary culture lifespan accelerated aging
Accesso online:	http://dx.doi.org/10.1080/15592294.2019.1626651
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