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Human aging DNA methylation signatures are conserved but accelerated in cultured fibroblasts

Aging is associated with progressive and site-specific changes in DNA methylation (DNAm). These global changes are captured by DNAm clocks that accurately predict chronological age in humans but relatively little is known about how clocks perform in vitro. Here we culture primary human fibroblasts a...

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Hlavní autoři: Gabriel Sturm, Andres Cardenas, Marie-Abèle Bind, Steve Horvath, Shuang Wang, Yunzhang Wang, Sara Hägg, Michio Hirano, Martin Picard
Médium: Artigo
Jazyk:Inglês
Vydáno: Taylor & Francis Group 2019-10-01
Edice:Epigenetics
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On-line přístup:http://dx.doi.org/10.1080/15592294.2019.1626651
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