Heritable ER stress impairs mitochondrial metabolism and maintenance of hematopoietic stem cells after low-dose irradiation

Summary: How hematopoietic stem cells (HSCs) respond to low doses of radiation currently used in medicine is largely unknown. Here, we show that HSC exposed to a single 20 mGy dose of irradiation (20 mGy-HSC) exhibit, when proliferating, oxidative stress and altered metabolism associated with increa...

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Ngā kaituhi matua:	Stephanie G. Moreno, Federica Ferri, Daniel Lewandowski, Vilma Barroca, Saiyiramii Devanand, Nathalie Dechamps, Paul-Henri Romeo, Nathalie Gault
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Elsevier 2026-02-01
Rangatū:	iScience
Ngā marau:	Cell biology
Urunga tuihono:	http://www.sciencedirect.com/science/article/pii/S2589004226001136
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!