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Revealing an outward-facing open conformational state in a CLC Cl–/H+ exchange transporter

CLC secondary active transporters exchange Cl- for H+. Crystal structures have suggested that the conformational change from occluded to outward-facing states is unusually simple, involving only the rotation of a conserved glutamate (Gluex) upon its protonation. Using 19F NMR, we show that as [H+] i...

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Principais autores: Chandra M Khantwal, Sherwin J Abraham, Wei Han, Tao Jiang, Tanmay S Chavan, Ricky C Cheng, Shelley M Elvington, Corey W Liu, Irimpan I Mathews, Richard A Stein, Hassane S Mchaourab, Emad Tajkhorshid, Merritt Maduke
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2016-01-01
Colecção:eLife
Assuntos:
antiporter
membrane exchanger
crystallization
principal component analysis
double electron-electron resonance spectroscopy
membrane protein
Acesso em linha:https://elifesciences.org/articles/11189
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