Molecular mechanism of exchange coupling in CLC chloride/proton antiporters

Abstract The ubiquitous CLC membrane transporters are unique in their ability to exchange anions for cations. Despite extensive study, there is no mechanistic model that fully explains their 2:1 Cl‒/H+ stoichiometric exchange mechanism. Here, we provide such a model. Using differential hydrogen-deut...

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Bibliographic Details

Main Authors:	Deniz Aydin, Chih-Ta Chien, Jürgen Kreiter, Amy R. Nava, Jasmina M. Portasikova, Lukas Fojtik, Briana L. Sobecks, Catalina Mosquera, Petr Man, Ron O. Dror, Wah Chiu, Merritt Maduke
Format:	Artigo
Language:	Inglês
Published:	Nature Portfolio 2026-01-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-025-68098-1
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