Dynamical model of the CLC-2 ion channel reveals conformational changes associated with selectivity-filter gating.
This work reports a dynamical Markov state model of CLC-2 "fast" (pore) gating, based on 600 microseconds of molecular dynamics (MD) simulation. In the starting conformation of our CLC-2 model, both outer and inner channel gates are closed. The first conformational change in our dataset involves rot...
Sábháilte in:
| Príomhchruthaitheoirí: | , , , |
|---|---|
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe / Cruthaithe: |
Public Library of Science (PLoS)
2020-03-01
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| Sraith: | PLoS Computational Biology |
| Rochtain ar líne: | https://doi.org/10.1371/journal.pcbi.1007530 |
| Clibeanna: |
Níl clibeanna ann, Bí ar an gcéad duine le clib a chur leis an taifead seo!
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