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Amyloid fibril formation kinetics of low-pH denatured bovine PI3K-SH3 monitored by three different NMR techniques

Introduction: Misfolding of amyloidogenic proteins is a molecular hallmark of neurodegenerative diseases in humans. A detailed understanding of the underlying molecular mechanisms is mandatory for developing innovative therapeutic approaches. The bovine PI3K-SH3 domain has been a model system for ag...

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I tiakina i:
Ngā kaituhi matua: Luis Gardon, Nina Becker, Nick Rähse, Christoph Hölbling, Athina Apostolidis, Celina M. Schulz, Kevin Bochinsky, Lothar Gremer, Henrike Heise, Nils-Alexander Lakomek
Hōputu: Artigo
Reo:Inglês
I whakaputaina: Frontiers Media S.A. 2023-11-01
Rangatū:Frontiers in Molecular Biosciences
Ngā marau:
amyloid fibrils
fibrillation
aggregation kinetics
NMR spectroscopy
PI3K-SH3
neurodegeneration
Urunga tuihono:https://www.frontiersin.org/articles/10.3389/fmolb.2023.1254721/full
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