Mechanism of beta-arrestin 1 mediated Src activation via Src SH3 domain revealed by cryo-electron microscopy

Abstract Beta-arrestins (βarrs) are key regulators and transducers of G-protein coupled receptor signaling; however, little is known of how βarrs communicate with their downstream effectors. Here, we delineate structural mechanisms underlying βarr-mediated signal transduction. Using cryo-electron mi...

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Bibliografiske detaljer

Principais autores:	Natalia Pakharukova, Brittany N. Thomas, Harsh Bansia, Linus Li, Dana K. Bassford, Rinat R. Abzalimov, Jihee Kim, Alem W. Kahsai, Biswaranjan Pani, Kunhong Xiao, Roni Ochakovski, Shibo Liu, Xingdong Zhang, Seungkirl Ahn, Amedee des Georges, Robert J. Lefkowitz
Format:	Artigo
Sprog:	Inglês
Udgivet:	Nature Portfolio 2026-02-01
Serier:	Nature Communications
Online adgang:	https://doi.org/10.1038/s41467-026-69884-1
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