Engineered CRISPR-Cas13a system with enhanced target RNA cleavage activity and reduced collateral activity for therapeutic applications

The CRISPR-Cas13 system exhibits potent RNA cleavage activity and has been widely utilized for RNA-targeting applications. However, its collateral cleavage of bystander RNAs limits in vivo therapeutic applications. In this study, we generated a series of LwaCas13a mutants through structure-based des...

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主要な著者:	Wenxia Zhang, Haili Wang, Dongzi Liu, Xi Mao, Yi Zhang, Yimu Yang, Zehui Liu, Tong Pan, Yingle Liu, Qi Zhang
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2026-03-01
シリーズ:	Molecular Therapy: Nucleic Acids
主題:	MT: Oligonucleotides: Therapies and Applications CRISPR-Cas13a crRNA cleavage activity collateral activity antiviral application
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S2162253125003658
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