Highly sensitive electrochemical assay based on strand displacement polymerization-assisted CRISPR/Cas12a collateral cleavage

In this work, a novel strand displacement polymerization strategy is designed with a single hairpin-structured DNA probe acting as both of primer and template. After target miRNA-induced structural transitions, extension and displacement reactions occur at the dimer with recycled target miRNA. The g...

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Autori principali:	Yulin Zhu, Xifeng Chen, Jiayue Shi, Haixuan Sun, Hua Chai, Peng Miao
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Elsevier 2023-12-01
Serie:	Electrochemistry Communications
Soggetti:	miRNA CRISPR/Cas12a Strand displacement amplification Silver nanoparticles Hairpin assembly
Accesso online:	http://www.sciencedirect.com/science/article/pii/S1388248123002047
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