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In Vitro Enzymatic and Kinetic Studies, and In Silico Drug-Receptor Interactions, and Drug-Like Profiling of the 5-Styrylbenzamide Derivatives as Potential Cholinesterase and β-Secretase Inhibitors with Antioxidant Properties

The 5-(styryl)anthranilamides were transformed into the corresponding 5-styryl-2-(<i>p</i>-tolylsulfonamido)benzamide derivatives. These 5-styrylbenzamide derivatives were evaluated through enzymatic assays in vitro for their capability to inhibit acetylcholinesterase (AChE), butyrylcholinesterase (...

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Autori principali: Malose J. Mphahlele, Emmanuel N. Agbo, Garland K. More, Samantha Gildenhuys
Natura: Artigo
Lingua:Inglês
Pubblicazione: MDPI AG 2021-04-01
Serie:Antioxidants
Soggetti:
5-styrylbenzamides
cholinesterase
β-secretase
antioxidant
metal chelating
drug-receptor interactions
Accesso online:https://www.mdpi.com/2076-3921/10/5/647
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