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Research Advances in How the cGAS-STING Pathway Controls the Cellular Inflammatory Response

Double-stranded DNA (dsDNA) sensor cyclic-GMP-AMP synthase (cGAS) along with the downstream stimulator of interferon genes (STING) acting as essential immune-surveillance mediators have become hot topics of research. The intrinsic function of the cGAS-STING pathway facilitates type-I interferon (IFN...

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Principais autores: Dongshan Wan, Wei Jiang, Junwei Hao
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020-04-01
Serier:Frontiers in Immunology
Fag:
inflammation
cGAS
STING
cGAMP
type I interferonopathies
Online adgang:https://www.frontiersin.org/article/10.3389/fimmu.2020.00615/full
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