Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

Abstract Chromatin acetylation, a critical regulator of synaptic plasticity and memory processes, is thought to be altered in neurodegenerative diseases. Here, we demonstrate that spatial memory and plasticity (LTD, dendritic spine formation) deficits can be restored in a mouse model of tauopathy fo...

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Hauptverfasser:	Snehajyoti Chatterjee, Raphaelle Cassel, Anne Schneider‐Anthony, Karine Merienne, Brigitte Cosquer, Laura Tzeplaeff, Sarmistha Halder Sinha, Manoj Kumar, Piyush Chaturbedy, Muthusamy Eswaramoorthy, Stéphanie Le Gras, Céline Keime, Olivier Bousiges, Patrick Dutar, Petnoi Petsophonsakul, Claire Rampon, Jean‐Christophe Cassel, Luc Buée, David Blum, Tapas K Kundu, Anne‐Laurence Boutillier
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Springer Nature 2018-10-01
Schriftenreihe:	EMBO Molecular Medicine
Schlagworte:	acetylation Alzheimer's disease CREB‐binding protein learning transcription
Online-Zugang:	https://doi.org/10.15252/emmm.201708587
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