Inhibition of AKT induces p53/SIRT6/PARP1-dependent parthanatos to suppress tumor growth

Abstract Background Targeting AKT suppresses tumor growth through inducing apoptosis, however, during which whether other forms of cell death occurring is poorly understood. Methods The effects of increasing PARP1 dependent cell death (parthanatos) induced by inhibiting AKT on cell proliferation wer...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Yizheng Zhang, Chuchu Zhang, Jiehan Li, Meimei Jiang, Shuning Guo, Ge Yang, Lingling Zhang, Feng Wang, Shiqi Yi, Jiangang Wang, Yang Fu, Yingjie Zhang
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2022-06-01
Serie:	Cell Communication and Signaling
Soggetti:	AKT p53 Parthanatos Cell death SIRT6 Colorectal cancer
Accesso online:	https://doi.org/10.1186/s12964-022-00897-1
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!