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PJ34 prevents cisplatin-induced hair cell loss via inhibition of PARP-1–AIF parthanatos

The poly (ADP-ribose) polymerase-1 (PARP-1) inhibitor PJ34 acts as an anti-inflammatory and neuroprotective agent by modulating parthanatos. This study aimed to explore the protective effects of PJ34 against cisplatin-induced injury in auditory cells and to elucidate its underlying mechanism of acti...

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Hoofdauteurs: Huiming Nong, Xiru Zhang, Yingxue Yuan, Junhong Zhang, Jingyi Zhao, Zhixin Cao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Association of Basic Medical Sciences of Federation of Bosnia and Herzegovina 2025-06-01
Reeks:Biomolecules & Biomedicine
Onderwerpen:
Hair cells
Hearing loss
Cisplatin
PARP inhibitor
AIF
Parthanatos
Online toegang:https://www.bjbms.org/ojs/index.php/bjbms/article/view/12533
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