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The rheumatoid arthritis drug auranofin exerts potent anti-lymphoma effect by stimulating TXNRD-mediated ROS generation and inhibition of energy metabolism

Since the survival of lymphoma patients who experience disease progression or relapse remains very poor, new therapeutic approaches and effective drugs are urgently needed. Here we show that auranofin (AF), an anti-rheumatoid drug thought to inhibit thioredoxin reductases (TXNRDs) as its mechanism o...

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Hlavní autoři: Mengqi Yang, Jiaxin Liu, Jianan Li, Shijun Wen, Yumin Hu, Wenhua Lu, Jinyun Liu, Peng Huang, Panpan Liu
Médium: Artigo
Jazyk:Inglês
Vydáno: Elsevier 2024-09-01
Edice:Redox Biology
Témata:
Lymphoma
Auranofin
TXNRD
ROS
ATP
Immune checkpoint
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2213231724002234
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