The rheumatoid arthritis drug auranofin exerts potent anti-lymphoma effect by stimulating TXNRD-mediated ROS generation and inhibition of energy metabolism

Since the survival of lymphoma patients who experience disease progression or relapse remains very poor, new therapeutic approaches and effective drugs are urgently needed. Here we show that auranofin (AF), an anti-rheumatoid drug thought to inhibit thioredoxin reductases (TXNRDs) as its mechanism o...

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Autors principals:	Mengqi Yang, Jiaxin Liu, Jianan Li, Shijun Wen, Yumin Hu, Wenhua Lu, Jinyun Liu, Peng Huang, Panpan Liu
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2024-09-01
Col·lecció:	Redox Biology
Matèries:	Lymphoma Auranofin TXNRD ROS ATP Immune checkpoint
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2213231724002234
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