Isoalantolactone induces AML pyroptosis and potentiates α-PD-1 efficacy by targeting selenoprotein TXNRD1
The suppressive microenvironment of AML limits anti-PD-1 efficacy, making pyroptosis induction a key strategy for its remodeling. Isoalantolactone (IAL), a naturally occurring small molecule, has been identified herein to inhibit cytosolic thioredoxin reductase1 (TXNRD1) and trigger pyroptosis in AM...
Guardado en:
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Elsevier
2026-04-01
|
| Colección: | Acta Pharmaceutica Sinica B |
| Materias: | |
| Acceso en línea: | http://www.sciencedirect.com/science/article/pii/S2211383525008482 |
| Etiquetas: |
Sin Etiquetas, Sea el primero en etiquetar este registro!
|