A direct interaction of cholesterol with the dopamine transporter prevents its out-to-inward transition.
Monoamine transporters (MATs) carry out neurotransmitter reuptake from the synaptic cleft, a key step in neurotransmission, which is targeted in the treatment of neurological disorders. Cholesterol (CHOL), a major component of the synaptic plasma membrane, has been shown to exhibit a modulatory effe...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Public Library of Science (PLoS)
2018-01-01
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| Serie: | PLoS Computational Biology |
| Accesso online: | https://doi.org/10.1371/journal.pcbi.1005907 |
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