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DHODH inhibition enhances the efficacy of immune checkpoint blockade by increasing cancer cell antigen presentation

Pyrimidine nucleotide biosynthesis is a druggable metabolic dependency of cancer cells, and chemotherapy agents targeting pyrimidine metabolism are the backbone of treatment for many cancers. Dihydroorotate dehydrogenase (DHODH) is an essential enzyme in the de novo pyrimidine biosynthesis pathway t...

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Principais autores: Nicholas J Mullen, Surendra K Shukla, Ravi Thakur, Sai Sundeep Kollala, Dezhen Wang, Nina Chaika, Juan F Santana, William R Miklavcic, Drew A LaBreck, Jayapal Reddy Mallareddy, David H Price, Amarnath Natarajan, Kamiya Mehla, David B Sykes, Michael A Hollingsworth, Pankaj K Singh
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications Ltd 2024-07-01
coleção:eLife
Assuntos:
DHODH
MHC-I
P-TEFb
pyrimidine nucleotide
antigen presentation
Brequinar
Acesso em linha:https://elifesciences.org/articles/87292
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