Research Progress on Mechanism of Action of DHODH in Progression of Malignant Tumors

Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent metabolic enzyme that oxidizes dihydroorotate acid to orotic acid in the de novo synthesis pathway of pyrimidine metabolism. DHODH is located in mitochondria, closely related to cellular oxidative phosphorylation, and an important suppressor...

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Hlavní autoři:	CHE Xin, HU Zhen, WANG Yonggang, LI Yaoping
Médium:	Artigo
Jazyk:	Chinês
Vydáno:	Magazine House of Cancer Research on Prevention and Treatment 2024-03-01
Edice:	Zhongliu Fangzhi Yanjiu
Témata:	dihydroorotate dehydrogenase neoplasms de novo pyrimidine biosynthesis oxphos ferroptosis dhodh inhibitor
On-line přístup:	http://www.zlfzyj.com/en/article/doi/10.3971/j.issn.1000-8578.2024.23.1067
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