A novel series of human dihydroorotate dehydrogenase inhibitors discovered by in vitro screening: inhibition activity and crystallographic binding mode

Human dihydroorotate dehydrogenase (DHODH), the enzyme that catalyzes the rate‐limiting step in de novo pyrimidine biosynthesis, is considered to be an attractive target for potential treatment of autoimmune disease and cancer. Here, we present a novel class of human DHODH inhibitors with high inhib...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Ting Zeng, Zeping Zuo, Youfu Luo, Yinglan Zhao, Yamei Yu, Qiang Chen
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Wiley 2019-08-01
Sarja:	FEBS Open Bio
Aiheet:	crystal structure dihydroorotate dehydrogenase drug inhibitor pyrimidine biosynthesis
Linkit:	https://doi.org/10.1002/2211-5463.12658
Tagit:	Lisää tagi Ei tageja, Lisää ensimmäinen tagi!