Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) features KRAS mutations in approximately 90% of human cases and excessive stromal response, termed desmoplastic reaction. Oncogenic KRAS drives pancreatic carcinogenesis by acting on both epithelial cells and tumor microenvironment (TME). W...

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Bibliografiska uppgifter

Huvudupphov:	Silvia Sozzi, Isabella Manni, Cristiana Ercolani, Maria Grazia Diodoro, Armando Bartolazzi, Francesco Spallotta, Giulia Piaggio, Laura Monteonofrio, Silvia Soddu, Cinzia Rinaldo, Davide Valente
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	BMC 2024-09-01
Serie:	Journal of Experimental & Clinical Cancer Research
Ämnen:	HIPK2 KRAS Pancreatic tumorigenesis
Länkar:	https://doi.org/10.1186/s13046-024-03189-3
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