Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) features KRAS mutations in approximately 90% of human cases and excessive stromal response, termed desmoplastic reaction. Oncogenic KRAS drives pancreatic carcinogenesis by acting on both epithelial cells and tumor microenvironment (TME). W...
Salvato in:
| Autori principali: | , , , , , , , , , , |
|---|---|
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
BMC
2024-09-01
|
| Serie: | Journal of Experimental & Clinical Cancer Research |
| Soggetti: | |
| Accesso online: | https://doi.org/10.1186/s13046-024-03189-3 |
| Tags: |
Nessun Tag, puoi essere il primo ad aggiungerne!!
|