Inactivation of HIPK2 attenuates KRASG12D activity and prevents pancreatic tumorigenesis
Abstract Background Pancreatic ductal adenocarcinoma (PDAC) features KRAS mutations in approximately 90% of human cases and excessive stromal response, termed desmoplastic reaction. Oncogenic KRAS drives pancreatic carcinogenesis by acting on both epithelial cells and tumor microenvironment (TME). W...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
BMC
2024-09-01
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| Sarja: | Journal of Experimental & Clinical Cancer Research |
| Aiheet: | |
| Linkit: | https://doi.org/10.1186/s13046-024-03189-3 |
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