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Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discr...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Mohammad Moad, Edouard Hannezo, Simon J. Buczacki, Laura Wilson, Amira El-Sherif, David Sims, Robert Pickard, Nicholas A. Wright, Stuart C. Williamson, Doug M. Turnbull, Robert W. Taylor, Laura Greaves, Craig N. Robson, Benjamin D. Simons, Rakesh Heer
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2017-08-01
Schriftenreihe:Cell Reports
Schlagworte:
stem cell
niche
prostate
epithelium
basal
luminal
branch
DLK1
Notch
organoids
prostate cancer
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2211124717310409
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