Multipotent Basal Stem Cells, Maintained in Localized Proximal Niches, Support Directed Long-Ranging Epithelial Flows in Human Prostates

Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discr...

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Autors principals:	Mohammad Moad, Edouard Hannezo, Simon J. Buczacki, Laura Wilson, Amira El-Sherif, David Sims, Robert Pickard, Nicholas A. Wright, Stuart C. Williamson, Doug M. Turnbull, Robert W. Taylor, Laura Greaves, Craig N. Robson, Benjamin D. Simons, Rakesh Heer
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2017-08-01
Col·lecció:	Cell Reports
Matèries:	stem cell niche prostate epithelium basal luminal branch DLK1 Notch organoids prostate cancer
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124717310409
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