Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling

Abstract Background Sepsis remains a leading cause of death in intensive care, and effective therapies that restore host adaptation are limited. The hypothalamus is a central hub that coordinates endocrine and immune homeostasis, yet how defined hypothalamic microcircuits are engaged in sepsis induc...

Descrizione completa

Dettagli Bibliografici

Autori principali:	Mengjie Che, Zhanpeng Feng, Wei Xu, Xufan Ling, Mingfeng Zhou, Junjie Peng, Guangsen Wu, Kai Li, Junxiang Peng, Ken Kin Lam Yung, Zhu Zhang, Hai Wang, Yonghua Cai, Xianqiu Liang, Xi’an Zhang, Songtao Qi, Yichao Ou
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2026-04-01
Serie:	Journal of Neuroinflammation
Soggetti:	Sepsis Arcuate nucleus Microglia ARHGAP24 Hypothalamus
Accesso online:	https://doi.org/10.1186/s12974-026-03786-3
Tags:	Aggiungi Tag Nessun Tag, puoi essere il primo ad aggiungerne!!