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Hypothalamic arcuate microglia in sepsis: AgRP circuit engagement and ARHGAP24-dependent remodeling

Abstract Background Sepsis remains a leading cause of death in intensive care, and effective therapies that restore host adaptation are limited. The hypothalamus is a central hub that coordinates endocrine and immune homeostasis, yet how defined hypothalamic microcircuits are engaged in sepsis induc...

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Main Authors: Mengjie Che, Zhanpeng Feng, Wei Xu, Xufan Ling, Mingfeng Zhou, Junjie Peng, Guangsen Wu, Kai Li, Junxiang Peng, Ken Kin Lam Yung, Zhu Zhang, Hai Wang, Yonghua Cai, Xianqiu Liang, Xi’an Zhang, Songtao Qi, Yichao Ou
Format: Artigo
Language:Inglês
Published: BMC 2026-04-01
Series:Journal of Neuroinflammation
Subjects:
Sepsis
Arcuate nucleus
Microglia
ARHGAP24
Hypothalamus
Online Access:https://doi.org/10.1186/s12974-026-03786-3
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