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Echs1-mediated histone crotonylation facilitates zygotic genome activation and expression of repetitive elements in early mammalian embryos

Abstract Histone crotonylation, a conserved post-translational histone modification, plays a crucial role in transcriptional regulation. However, its function in early embryonic development remains largely unexplored. Here, we perform genome-wide mapping of histone crotonylation in mouse and human e...

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Príomhchruthaitheoirí: Yong-feng Wang, Yu-ting Wan, Qian-rong Qi, Qing Tian, Xin-mei Liu, Qing-zhen Xie, Ying Yin, Li-quan Zhou
Formáid: Artigo
Teanga:Inglês
Foilsithe / Cruthaithe: Nature Portfolio 2025-07-01
Sraith:Nature Communications
Rochtain ar líne:https://doi.org/10.1038/s41467-025-60565-z
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