A Potential Blueprint for the Design of Biased Ligands for Aminergic GPCRs

G protein-coupled receptors (GPCRs) are omnipresent in the regulation of physiological processes and therefore account for the most prominent drug target class. However, nearly all drugs targeting GPCRs have been developed by the concept of receptors as simple on–off switches. This is surprising, be...

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Hlavní autor:	Marcel Bermudez
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	MDPI AG 2022-11-01
Edice:	Medical Sciences Forum
Témata:	GPCR biased signaling allosteric modulation protein dynamics drug design
On-line přístup:	https://www.mdpi.com/2673-9992/14/1/149
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