Intramolecular activity regulation of adhesion GPCRs in light of recent structural and evolutionary information

The class B2 of GPCRs known as adhesion G protein-coupled receptors (aGPCRs) has come under increasing academic and nonacademic research focus over the past decade due to their physiological importance as mechano-sensors in cell-cell and cell-matrix contexts. A major advance in understanding signal...

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Autores principales:	Gunnar Kleinau, Amal Hassan Ali, Franziska Wiechert, Michal Szczepek, Andrea Schmidt, Christian M.T. Spahn, Ines Liebscher, Torsten Schöneberg, Patrick Scheerer
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2023-11-01
Colección:	Pharmacological Research
Materias:	G protein-coupled receptor Adhesion GPCR AGPCR Tethered agonist Stachel sequence Intramolecular agonist
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S1043661823003274
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