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A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates

Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies. PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that express the surface antigen VAR2CSA and bind to chondroitin sulfate A (CSA) in the placenta. Women become PM-resistant over...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Justin YA Doritchamou, Jonathan P Renn, Bethany Jenkins, Almahamoudou Mahamar, Alassane Dicko, Michal Fried, Patrick E Duffy
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications Ltd 2022-02-01
Schriftenreihe:eLife
Schlagworte:
pregnancy
malaria
vaccine
VAR2CSA
variant
blocking antibody
Online-Zugang:https://elifesciences.org/articles/76264
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