Identification and Biological Evaluation of a Novel CLK4 Inhibitor Targeting Alternative Splicing in Pancreatic Cancer Using Structure‐Based Virtual Screening

Abstract Pancreatic cancer is an aggressive malignancy with a poor prognosis and limited treatment options. Cdc‐like kinase 4 (CLK4), a kinase that regulates alternative splicing by phosphorylating spliceosome components, is implicated in aberrant splicing events driving pancreatic cancer progressio...

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Egile Nagusiak:	Chun‐Lin Yang, Yi‐Wen Wu, Huang‐Ju Tu, Yun‐Hsuan Yeh, Tony Eight Lin, Tzu‐Ying Sung, Mu‐Chun Li, Shih‐Chung Yen, Jui‐Hua Hsieh, Ming‐Chin Yu, Sen‐Yung Hsieh, Hsing‐Pang Hsieh, Shiow‐Lin Pan, Kai‐Cheng Hsu
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Wiley 2025-05-01
Saila:	Advanced Science
Gaiak:	alternative splicing CLK4 kinase inhibitor pancreatic cancer structure‐based virtual screening
Sarrera elektronikoa:	https://doi.org/10.1002/advs.202416323
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