CLK2 Condensates Reorganize Nuclear Speckles and Induce Intron Retention

Abstract Intron retention (IR) constitutes a less explored form of alternative splicing, wherein introns are retained within mature mRNA transcripts. This investigation demonstrates that the cell division cycle (CDC)‐like kinase 2 (CLK2) undergoes liquid–liquid phase separation (LLPS) within nuclear...

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Detalles Bibliográficos

Principais autores:	Bing Wang, Jing Li, Yanyang Song, Xuhui Qin, Xia Lu, Wei Huang, Chentai Peng, Jinxia Wei, Donghui Huang, Wei Wang
Formato:	Artigo
Idioma:	Inglês
Publicado:	Wiley 2024-10-01
Series:	Advanced Science
Assuntos:	CLK2 condensates heat shock intron retention nuclear speckles
Acceso en liña:	https://doi.org/10.1002/advs.202309588
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