Stable H-bond networks are crucial for selective CLK1 inhibition: a computational perspective
Studying the selectivity mechanism of inhibitors towards highly similar isoforms is an important task in the development of new drugs, which are designed to avoid the undesired side effects in vivo. CDC-like kinase isoforms (CLKs) are serine/threonine protein kinases that are involved in the phospho...
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| Glavni autori: | , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Frontiers Media S.A.
2025-06-01
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| Serija: | Frontiers in Chemistry |
| Teme: | |
| Online pristup: | https://www.frontiersin.org/articles/10.3389/fchem.2025.1582515/full |
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