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Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies

Abstract The tumor suppressor p53, often referred to as the “guardian of the genome,” is mutated in more than half of human cancers. These mutations have a significant impact on cancer biology and response to therapy. p53 mutations involve a range of changes that interfere with DNA binding, eliminat...

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Main Authors: H. Helena Wu, Sarah Leng, David D. Eisenstat, Consolato Sergi, Roger Leng
Format: Artigo
Language:Inglês
Published: BMC 2026-03-01
Series:Cellular & Molecular Biology Letters
Subjects:
p53 tumor suppressor
Mutation
Gain-of-function
Cancer progression
Cancer therapy
Online Access:https://doi.org/10.1186/s11658-026-00907-x
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