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Targeting mutant p53 in cancer: from mechanistic insights to therapeutic strategies

Abstract The tumor suppressor p53, often referred to as the “guardian of the genome,” is mutated in more than half of human cancers. These mutations have a significant impact on cancer biology and response to therapy. p53 mutations involve a range of changes that interfere with DNA binding, eliminat...

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-д хадгалсан:
Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: H. Helena Wu, Sarah Leng, David D. Eisenstat, Consolato Sergi, Roger Leng
Формат: Artigo
Хэл сонгох:Inglês
Хэвлэсэн: BMC 2026-03-01
Цуврал:Cellular & Molecular Biology Letters
Нөхцлүүд:
Онлайн хандалт:https://doi.org/10.1186/s11658-026-00907-x
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