Identification and external validation of a prognostic signature based on N6-methyladenosine- and tertiary lymphoid structures-related genes to evaluate survival prognosis and treatment efficacy in lung adenocarcinoma

Abstract Background The N6-Methyladenosine (m6A) RNA modification critically regulates cancer biology, and tertiary lymphoid structures (TLSs) shape antitumor immunity. However, their combined prognostic roles in lung adenocarcinoma (LUAD) remain unclear. This study applies an integrative multi-omic...

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Hlavní autoři:	Xiangbao Yang, Chengwen Zheng, Yinpeng Pan, Shuoming Wu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Springer 2025-12-01
Edice:	Discover Oncology
Témata:	Tertiary lymphoid structures N6-methyladenosine Lung adenocarcinoma Machine learning Mult omics Prognostic model
On-line přístup:	https://doi.org/10.1007/s12672-025-04318-w
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