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BRCA-associated hereditary male cancers: can gender affect the prevalence and spectrum of germline pathogenic variants?

IntroductionAlthough hereditary male neoplasms are quite rare, individuals harbouring germline BRCA1/2 pathogenic variants (PVs) may have a risk of developing tumours associated with Hereditary Breast and Ovarian Cancer (HBOC) syndrome, including male breast (MBC), prostate (PCa) and pancreatic (PC)...

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Hoofdauteurs: Daniele Fanale, Lidia Rita Corsini, Chiara Brando, Ugo Randazzo, Marco Bono, Erika Pedone, Alessandro Perez, Roberta Sciacchitano, Daniela Cancelliere, Paola Piraino, Ambra Giurintano, Tancredi Didier Bazan Russo, Pietro Ferraro, Gaetana Rinaldi, Valeria Spinnato, Vincenzo Gennusa, Gianfranco Pernice, Salvatore Vieni, Gianni Pantuso, Antonio Russo, Viviana Bazan
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2024-06-01
Reeks:Frontiers in Oncology
Onderwerpen:
BRCA1
BRCA2
germline pathogenic variants
HBOC
male breast cancer
melanoma
Online toegang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1414343/full
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