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Novel dicarbonyl metabolic pathway via mitochondrial ES1 possessing glyoxalase III activity

Glycation, caused by reactive dicarbonyls, plays a role in various diseases by forming advanced glycation end products. In live cells, reactive dicarbonyls such as glyoxal (GO) and methylglyoxal (MGO) are produced during cell metabolism, and these should be removed consistently. However, the dicarbo...

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Principais autores: Ginga Ito, Yota Tatara, Ken Itoh, Miwa Yamada, Tetsuro Yamashita, Kimitoshi Sakamoto, Takayuki Nozaki, Kinji Ishida, Yui Wake, Takehito Kaneko, Tomokazu Fukuda, Eriko Sugano, Hiroshi Tomita, Taku Ozaki
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2023-01-01
coleção:BBA Advances
Assuntos:
Mitochondria
ES1
Reactive dicarbonyl
Glyoxalase
Methylglyoxal degradation
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2667160323000212
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