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Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice

Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is essential for a satisfactory therapeutic outcome. For more versa...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Prakashkumar Dobariya, Wei Xie, Swetha Pavani Rao, Jiashu Xie, Davis M. Seelig, Robert Vince, Michael K. Lee, Swati S. More
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2024-05-01
Schriftenreihe:Antioxidants
Schlagworte:
acetaminophen
glyoxalase 1
ψ-glutathione
hepatotoxicity
methylglyoxal
advanced glycation end product
Online-Zugang:https://www.mdpi.com/2076-3921/13/6/648
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