Deletion of Glyoxalase 1 Exacerbates Acetaminophen-Induced Hepatotoxicity in Mice

Acetaminophen (APAP) overdose triggers a cascade of intracellular oxidative stress events, culminating in acute liver injury. The clinically used antidote, N-acetylcysteine (NAC), has a narrow therapeutic window, and early treatment is essential for a satisfactory therapeutic outcome. For more versa...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй

Үндсэн зохиолчид:	Prakashkumar Dobariya, Wei Xie, Swetha Pavani Rao, Jiashu Xie, Davis M. Seelig, Robert Vince, Michael K. Lee, Swati S. More
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	MDPI AG 2024-05-01
Цуврал:	Antioxidants
Нөхцлүүд:	acetaminophen glyoxalase 1 ψ-glutathione hepatotoxicity methylglyoxal advanced glycation end product
Онлайн хандалт:	https://www.mdpi.com/2076-3921/13/6/648
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!