Platelets induce free and phospholipid-esterified 12-hydroxyeicosatetraenoic acid generation in colon cancer cells by delivering 12-lipoxygenase

Platelets promote tumor metastasis by inducing promalignant phenotypes in cancer cells and directly contributing to cancer-related thrombotic complications. Platelet-derived extracellular vesicles (EVs) can promote epithelial-mesenchymal transition (EMT) in cancer cells, which confers high-grade mal...

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Principais autores:	Annalisa Contursi, Simone Schiavone, Melania Dovizio, Christine Hinz, Rosa Fullone, Stefania Tacconelli, Victoria J. Tyrrell, Rosalia Grande, Paola Lanuti, Marco Marchisio, Mirco Zucchelli, Patrizia Ballerini, Angel Lanas, Valerie B. O'Donnell, Paola Patrignani
Formato:	Artigo
Idioma:	Inglês
Publicado:	Elsevier 2021-01-01
Series:	Journal of Lipid Research
Assuntos:	blood platelets 12-HETE 12-Lipoxygenase extracellular vesicles colorectal cancer plasma membrane phospholipids
Acceso en liña:	http://www.sciencedirect.com/science/article/pii/S0022227521000912
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