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The Tip of the Four N-Terminal α-Helices of Clostridium sordellii Lethal Toxin Contains the Interaction Site with Membrane Phosphatidylserine Facilitating Small GTPases Glucosylation

Clostridium sordellii lethal toxin (TcsL) is a powerful virulence factor responsible for severe toxic shock in man and animals. TcsL belongs to the large clostridial glucosylating toxin (LCGT) family which inactivates small GTPases by glucosylation with uridine-diphosphate (UDP)-glucose as a cofacto...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Carolina Varela Chavez, Georges Michel Haustant, Bruno Baron, Patrick England, Alexandre Chenal, Serge Pauillac, Arnaud Blondel, Michel-Robert Popoff
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2016-03-01
Schriftenreihe:Toxins
Schlagworte:
Clostridium sordellii
Clostridium difficile
large clostridial glucosylating toxin
C. sordellii lethal toxin
phosphatidylserine
Ras
Online-Zugang:http://www.mdpi.com/2072-6651/8/4/90
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