The Essential Role of Rac1 Glucosylation in Clostridioides difficile Toxin B-Induced Arrest of G1-S Transition

Clostridioides difficile infection (CDI) in humans causes pseudomembranous colitis (PMC), which is a severe pathology characterized by a loss of epithelial barrier function and massive colonic inflammation. PMC has been attributed to the action of two large protein toxins, Toxin A (TcdA) and Toxin B...

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Үндсэн зохиолчид:	Lara Petersen, Svenja Stroh, Dennis Schöttelndreier, Guntram A. Grassl, Klemens Rottner, Cord Brakebusch, Jörg Fahrer, Harald Genth
Формат:	Artigo
Хэл сонгох:	Inglês
Хэвлэсэн:	Frontiers Media S.A. 2022-03-01
Цуврал:	Frontiers in Microbiology
Нөхцлүүд:	cyclin D cell cycle p21-activated kinase human intestinal organoids large clostridial glucosylating toxins colonic epithelial renewal
Онлайн хандалт:	https://www.frontiersin.org/articles/10.3389/fmicb.2022.846215/full
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!