HLA allele profiling and association in Thai patients with confirmed beta-lactam hypersensitivity: an NGS-based analysis

BackgroundBeta-lactams (BLs) are the most common reported antibiotics associated with hypersensitivity reactions (HSRs). However, evidence for human leukocyte antigen (HLA) associations with beta-lactam hypersensitivity reaction (BL-HSR) remains limited and population-specific, particularly in the T...

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Autori principali:	Lalita Lumkul, Prapasri Kulalert, Mongkhon Sompornrattanaphan, Thanachit Krikeerati, Supharat Suvichapanich, Patcharawadee Thongkumkoon, Pitiporn Noisagul, Chamard Wongsa, Torpong Thongngarm, Wannada Laisuan, Dumnoensun Pruksakorn, Padcha Pongcharoen, Sira Nanthapisal, Ratchaya Lertnawapan, Phichayut Phinyo
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-07-01
Serie:	Frontiers in Pharmacology
Soggetti:	allergy antibiotics beta-lactam hypersensitivity reactions genetic association human leukocyte antigen HLA
Accesso online:	https://www.frontiersin.org/articles/10.3389/fphar.2026.1782094/full
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